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Fig. 6
Expression of disc1 in EGFP expressing cells is down-regulated by cyclopamine treatment. Cyclopamine (40µm) was applied to Tg(olig2:egfp) embryos from 34hpf prior to the main period of OPC proliferation and migration. Cyclopamine-treated embryos (D) showed a loss of midline disc1 expression (black arrows) at 50hpf compared to untreated embryos (C). Comparison of B with A shows a loss of EGFP-positive OPCs as a result of chemical inhibition of Shh signal transduction (green arrows). 10 animals were imaged from each group. All images are of transverse sections.
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