ZFIN Image: Xu et al., 2015, Fig. S3

Image

Figure Caption

Fig. S3

The cmybhkz3 Mutants Exhibit a Developmental Delay and Lack T Lymphocytes and Erythrocytes.

(A) Imaging of 20 dpf WT and cmyb^hkz3 mutant. The upper larva is the WT and the lower larva is the cmyb^hkz3 mutant. The scale bar represents 2 mm.

(B) Quantification of total body length of 20 dpf WT (n=11), cmyb^hkz3 mutant (n=10) and 15 dpf WT larvae (n=11). Error bars represent mean SEM. ***, P<0.001.

(C) T cell marker rag1 is greatly reduced in 20 dpf cmyb^hkz3 mutants (lower panel) comparing with WT (upper panel). Red arrows indicate the position of thymus.

(D) Only trace amount of erythrocyte marker hemoglobin αe1 is detected in the cmyb^hkz3 mutant (lower panel) comparing with WT (upper panel) at 20 dpf. White arrows indicate erythrocytes in the tail region.

Acknowledgments

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Reprinted from Developmental Cell, 34, Xu, J., Zhu, L., He, S., Wu, Y., Jin, W., Yu, T., Qu, J.Y., Wen, Z., Temporal-Spatial Resolution Fate Mapping Reveals Distinct Origins for Embryonic and Adult Microglia in Zebrafish, 632-641, Copyright (2015) with permission from Elsevier. Full text @ Dev. Cell