ZFIN Image: Chen et al., 2012, Fig. 3

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Figure Caption

Fig. 3

12G9 and 36E9 induced morphological changes in differentiated melanocytes. All embryos were treated from 30 to 48 hpf except in A and B. Lateral view, anterior to the left and dorsal to the top. A, C, E, G, and I show the pictures of live embryos; B, D, F, H, and J show the dct in situ hybridization. (A and B) 30 hpf embryos before treatment. (C and D) Embryos treated with DMSO had stellate melanocytes, and the pattern of dct positive cells matched the melanocytes. (E and F) Embryos treated with PTU had less melanin, and the dct expression pattern was normal. Embryos treated with compound 12G9 (G and H) or 36E9 (I and J) had less pigmentation, condensed melanocytes, and severely reduced number of dct positive cells.

Acknowledgments

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