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Fig. 5
MEK inhibitor U0126 suppresses proliferative effect of oncogenic KRAS in skin epithelial cells. (A) Graphic representation of driver and effector DNA constructs for generation of Dox-inducible stable transgenic lines. (B, C) In an inducible Tg(krt5:rtTA:mCherryKRASG12V) transgenic line, 48hpf larvae treated with 10 µg/ml Dox showed skin hyperplasia, most noticeably under the yolk sac (arrows). 50 µM U0126 treatment completely eliminated the skin hyperplasia (arrow heads). Scale bar, 250 µm.
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