ZFIN Image: Yang et al., 2015, Fig. 1

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Figure Caption

Fig. 1

The vu76 mutation causes defects in pigment deposition and oligodendrocyte development. Images of living wild-type (A) and vu76 mutant (B) larvae at 6 dpf. The mutant has a smaller brain (bracket) and eye (e) than wild-type and lacks a swim bladder (sb). Lateral (C,E) and dorsal (D,F) views of 5 dpf wild-type and vu76 mutant larvae to show pigment patterns. The dark pigment of the mutant is more broadly distributed than that of the wild-type. Low (G,H) and high (I,J) magnification images of Tg(olig2:EGFP) reporter gene expression in wild-type and mutant larvae. Images are focused on the trunk spinal cord (sc, brackets) with dorsal up. In G and H dorsally migrated OPCs appear as green dots (arrows). Fewer dorsal OPCs are apparent in the vu76 mutant larva than in the wild-type larva. At 6 dpf OPC and oligodendrocyte processes form a dense meshwork (I, boxed area magnified as inset). Oligodendrocyte lineage cell processes are evident in the mutant larva, but the density of processes is less than in wild-type (J, boxed area magnified as inset).

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Acknowledgments

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