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Fig. S6
Additional Marker Analyses in chd8 Morphants, Related to Figure 4
Embryos were injected with 4 ng of chd8-MO1 or 4 ng chd8-MO2. Paired-box 6 (pax6) is a marker of the eye region and the telencephalon. Expression of pax6 at 24 hr stage, top view. Arrows point at the eye region and arrowhead points at the telencephalon region. No significant change is observed for pax6 expression (top panels). Expression of krox20 at 24 hr stage, lateral view. Rhombomere 3 (r3) and 5 (r5) of the hindbrain is labeled. No significant change is observed (bottom panels).
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Reprinted from Cell, 158(2), Bernier, R., Golzio, C., Xiong, B., Stessman, H.A., Coe, B.P., Penn, O., Witherspoon, K., Gerdts, J., Baker, C., Vulto-van Silfhout, A.T., Schuurs-Hoeijmakers, J.H., Fichera, M., Bosco, P., Buono, S., Alberti, A., Failla, P., Peeters, H., Steyaert, J., Vissers, L.E., Francescatto, L., Mefford, H.C., Rosenfeld, J.A., Bakken, T., O'Roak, B.J., Pawlus, M., Moon, R., Shendure, J., Amaral, D.G., Lein, E., Rankin, J., Romano, C., de Vries, B.B., Katsanis, N., Eichler, E.E., Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development, 263-76, Copyright (2014) with permission from Elsevier. Full text @ Cell