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Fig. S3 PGE2 influences Liver vs. Pancreas Specification (Related to Figure 3) (A) Double in situ hybridization for trypsin and lfabp at 96 hpf reveals reciprocal effects on organ size following exposure to dmPGE2 or Indo at 12-20 hpf. Early exposure to dmPGE2 or Indo results in opposing effects on the developing liver and pancreas. Left lateral view.
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Reprinted from Developmental Cell, 28(4), Nissim, S., Sherwood, R.I., Wucherpfennig, J., Saunders, D., Harris, J.M., Esain, V., Carroll, K.J., Frechette, G.M., Kim, A.J., Hwang, K.L., Cutting, C.C., Elledge, S., North, T.E., and Goessling, W., Prostaglandin E2 regulates liver versus pancreas cell-fate decisions and endodermal outgrowth, 423-437, Copyright (2014) with permission from Elsevier. Full text @ Dev. Cell