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Fig. 1 Pleiotropic action of cerebum deficiencies on zebrafish development. (A) WT diploid pharyngula and (B) crmc4 mutant sibling at the 26 somite stage. The crm mutant is characterized by a reduced brain and eyes, and an abnormal accumulation of cells caudal to the anus (arrow). (C) WT embryo and (D) crmc4 sibling at the 8 somite stage. The mutant exhibits a shorter axis, a shallower anterior neural keel (arrow), and an enlarged tailbud (arrowheads). Scale bars, 200 μm.
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