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Fig. S1
Sequences and Expression of the dkk Family and krm Genes, Related to Figures 1 and 2
(A) Amino acid sequences of mouse and zebrafish Dkk family proteins were compared. Boxes indicate putative signal peptide sequences and the cysteine rich domain (CRD1 and CRD2).
(B) Phylogenetic tree for the dkk gene family.
(C) Neither dkk1a nor dkk1b were not detectably expressed in neuromasts in 48hpf. Scale bar represents 50 μm.
(D) Amino acid sequences of mouse and zebrafish Krm were compared. Boxes indicate putative signal peptide sequences and the transmembrane domain.
(E) Phylogenetic tree for the krm gene family. In all of four teleost species analyzed (zebrafish, fugu, Tetraodon and medaka), a single krm gene was found in the Sanger Centre genome database.
(F) krm was broadly expressed in neuromasts in 48hpf. The neuromast is outlined. Scale bar represents 20 μm.