|
Fig. S1 Anteriorly expanded pax8, caused by activation of RA signaling, is patterned by BMP signaling with the same temporal dynamics as the normal posterior domain. (A-E) Expression of pax8 (arrowheads) in wild type (A, n=42/42) and in Tg(hsp70:chd) heat shocked at sphere (B, n=38/38), 40% epiboly (C, n=28/31), 50% epiboly (D, n=31/35) and shield (E, n=30/31) stage. (F-J) pax8 expression in RA-treated wild type (F, n=38/39) and RA-treated and heat shocked Tg(hsp70:chd) at sphere (G, n=30/30), 40% epiboly (H, n=31/35), 50% epiboly (I, n=32/34) and shield (J, n=37/38) stage. Lateral views, dorsal to right with anterior to top, except for insets in A and F, which are dorsal views with anterior to top. All are at the 6-somite stage.