ZFIN Image: Bielen et al., 2012, Fig. 3

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Fig. 3

BMP Signaling Is Active at the Rostral Margin of the Neural Plate during Early Gastrulation(A–H) Whole-mount P-Smad1,5,8 antibody staining (green) and dlx3 transcript detection (red) in 60% epiboly (early gastrula, A–D) and bud stage (end gastrula, E–H). White lines mark the border of dlx3 expression. (A–D) Animal pole view, dorsal to the right. (E–H) Dorsal view, anterior to the left. (D) is a 40× magnification of the yellow boxed area in (C). (H) is a close-up of the yellow boxed area in (G). All figures are z-projections of confocal sections. nne, nonneural ectoderm; preT, prospective telencephalon; Epi, epidermis; PP, preplacodal territory; Tel, telencephalon.

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Acknowledgments

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Reprinted from Developmental Cell, 23(4), Bielen, H., and Houart, C., BMP Signaling Protects Telencephalic Fate by Repressing Eye Identity and Its Cxcr4-Dependent Morphogenesis, 812-822, Copyright (2012) with permission from Elsevier. Full text @ Dev. Cell