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Fig. 4

ID
ZDB-IMAGE-130103-24
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Figures for Bonner et al., 2012
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Figure Caption

Fig. 4 robo2 and robo3 are required for commissure formation. A-B Confocal microscopic images of WT and ast-/- commissures from individual CoPA axons (lateral view). astti272z CoPA axons ascend in the midline while WT CoPA axons cross immediately. Anterior is to the left, dorsal is up. Gray dotted line indicates ventral midline of spinal cord. C Measurements of axon length within the midline of the spinal cord, in the anteroposterior axis (arbitrary units) in wild-type, astti272z, and twt embryos. astti272z commissure length is 36 ± 3.2 (n = 7), which is 2.8 times that of wild type, which measures 13.3 ± 1.1 (n = 19) . In affected twttx209embryos, the average length is roughly 15 times that of WT (204 ± 22.9; n = 9).

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