ZFIN Image: Ni et al., 2012, Fig. S4

Image

Figure Caption

Fig. S4 Hepatocyte-specific Cre activity in hepatocyte-Cre embryos. (A) Double carriers of hepatocyte-Cre/Tg(eab2:[EGFP-T-mCherry]) were imaged at 5 dpf. Expression of the red fluorescent protein mCherry indicates Cre activity. (B–D) Hepatocyte-Cre does not rescue defects in intestinal epithelium. At 5 dpf, the intestinal epithelium in wild-type larvae is polarized and well organized with little cell death (B). In contrast, the intestinal epithelium in supv3l1^GtT/GtT mutants is disorganized with no apparent apical–basal polarity and abundant cell death (arrows) (C). Despite rescue of mature hepatocytes, the intestinal epithelium in supv3l1^LKO mutant is still disorganized with no apparent apical–basal polarity and abundant cell death (arrows) (D).

Acknowledgments

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