ZFIN Image: Abrams et al., 2012, Fig. 7

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Fig. 7

Bmb Is Required for Pronuclear Fusion(A) At 16 mpf, WT pronuclei are fully congressed.(B) Some WT pronuclei begin to fuse at 16 mpf.(C) At 19 mpf, WT pronuclear fusion is complete.(D) At 22 mpf, in WT embryos a single condensed DNA mass is detected at the first prometaphase.(E) At 16 mpf, bmb pronuclei are fully congressed.(F) At 19 mpf, bmb pronuclei fail to fuse as chromatin begins to condense.(G) At 22 min, two separate condensed DNA masses are detected in bmb embryos at the first prometaphase. Scale bars, 10 μm. At each time point, n e 4. Images correspond to Z-projections of individual confocal Z-planes. WT TL males were crossed to female bmb mutants in (E)–(G).

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Acknowledgments

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Reprinted from Cell, 150(3), Abrams, E.W., Zhang, H., Marlow, F.L., Kapp, L., Lu, S., and Mullins, M.C., Dynamic Assembly of Brambleberry Mediates Nuclear Envelope Fusion during Early Development, 521-532, Copyright (2012) with permission from Elsevier. Full text @ Cell