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Fig. 7
Magnesium sulfate administration protects against hypoxia-related axon pathfinding defects.
(A) C/L intensity ratios of increasing magnesium concentrations (mM). *p<0.01; ** p<0.001. Error bars SEM. (B, C) Magnesium reduces activation of the hif1α pathway, as shown by decreased igfbp-1 expression following hypoxia and concurrent magnesium exposure from 24–36 hpf. Bright-field images; ventral views, rostral top, scale bar 50 μm. (D) C/L intensity ratios shows rescue by magnesium of DMOG exposure from 24–36 hpf. *p<0.05. Error bars SEM.
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