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Fig. S3 Otic vesicle defects following loss of grhl2b and persistence of grhl2b in mutant midbrain. (A,B) Loss of otoliths is visible in grhl2b morphants; these can be rescued by re-injection with Grhl2 mRNA (arrows; B). (C-F) Fish injected with the grhl2b-ATG MO show loss of otic cldnb (C) and epcam (D) expression, relative to controls (E,F). (G,H) Although expression in the olfactory epithelium (oe) and otic vesicle (ov) is greatly reduced in homozygous-null grhl2b mutants (homo; G), expression of grhl2b in the midbrain (m) is only slightly reduced compared with wild-type fish (WT; H).
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