ZFIN Image: Dalgin et al., 2011, Fig. 6

Image

Figure Caption

Fig. 6 Mnx1 functions directly in the endoderm to promote beta cell fate. (A) The cell transplantation approach. Wild-type zebrafish embryos were injected with fluorescein dextran (green) together with either sox32 mRNA or sox32 mRNA and Mnx1 MO. Control or morphant donor cells were transplanted into sox32 morphant hosts then raised until 28 hpf. (B-C′) Confocal images of representative 28 hpf control (B,B′) and Mnx1 MO (C,C′) transplants, at low (B,C) and higher (B′,C′) magnification, showing whole-mount immunostaining for myosin (blue) and in situ hybridization for insulin (red). S1, first somite. Anterior to left. Control, n=12; Mnx1 MO, n=13.

Acknowledgments

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