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Fig. S6
related to Figure 7: Expression of Connexin-31 with a C86S mutation, but not wild-type Connexin-31, causes apoptosis in the tail epidermis of zebrafish embryos.
Heat-shock for 30 minutes triggers nearly ubiquitous expression of the (wt)Cx31-EGFP (A,B) and (C86S)Cx31-EGFP but not of cmlc2 (C, D). After 30 min of heat-shock, a severe phenotype is observed in (C86S)Cx31-EGFP injected embryos (G,H) with disruption of skin epidermis as compared to (wt)Cx31-EGFP injected embryos (E,F). (white arrowhead shows expression of cmlc2-EGFP in the heart)
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Reprinted from Developmental Cell, 21(3), Pyati, U.J., Gjini, E., Carbonneau, S., Lee, J.S., Guo, F., Jette, C.A., Kelsell, D.P., and Look, A.T., p63 Mediates an Apoptotic Response to Pharmacological and Disease-Related ER Stress in the Developing Epidermis, 492-505, Copyright (2011) with permission from Elsevier. Full text @ Dev. Cell