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Fig. S1
PTU lessens teratogenic effect of retinoic acid on neural crest. 72 hpf Tg(sox10::EGFP) embryos (ventral view) were treated with 100 nM retinoic acid (RA; A,B) at 28 hpf or 0.1% dimethylsulfoxide (DMSO; I–L) in the roy background (in the absence of PTU, A, C) or presence of 0.003% PTU (B, D) which was added to the media at 12 hpf. Exogenous retinoic acid inhibited neural crest-derived pharyngeal arch (PA) formation, which was worse in the absence of PTU (B, D compared to A, C).
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