ZFIN Image: Wang et al., 2011, Fig. 1

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Figure Caption

Fig. 1

Genetic ablation of adult zebrafish cardiomyocytes. (A) Schematic representation of transgenes used for zebrafish cardiomyocyte ablation. DTA is specifically expressed in cardiomyocytes upon 4-HT treatment. (B) TUNEL staining of ventricular muscle from transgenic animals injected with vehicle or 4-HT (0.5 mg/ml). Arrowheads indicate TUNEL-positive cardiac myocytes. (C) Myosin heavy chain (MHC) staining of ventricular sections after vehicle or 4-HT injection, shown at 7 days post-injection (dpi). (D) Mef2 staining to indicate cardiomyocyte nuclei, showing major cellular losses in 4-HT-injected animals. Scale bars: 50 μm.

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