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Fig. 9
Blocking Ras function greatly enhances ectopic hepatocyte formation induced by Wnt8a overexpression. (A-D) Embryos obtained from crossing Tg(hs:wnt8a) with Tg(hs:dnRas) zebrafish were heat-shocked at 30 hpf, and harvested at 64 hpf for whole-mount immunostaining. Overexpression of dnRas did not induce ectopic hepatocytes or affect liver size in controls (B, n=5 out of 5), but it greatly enhanced ectopic hepatocyte formation induced by Wnt8a overexpression [D (n=7 out of 7) versus C (n=8 out of 8), brackets]. Ventral views, anterior upwards. Scale bar: 50 μm.
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