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Fig. S10
Targeted Knockdown of bmp4 Results in a Loss of HSC-Derived Thymocytes All embryos depicted are from the same experiment, representative embryos are shown.
a, b) runx1 expression (red arrowheads) was absent in 26hpf embryos injected with bmp4 morpholino (MO). c-f) foxn1 expression in 4dpf thymi was unaffected (c, d) but rag1 expression was inhibited in 12/17 embryos (e, f). All embryos were treated with 0.003% phenylthiourea to eliminate melanocyte pigmentation.
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Reprinted from Developmental Cell, 16(6), Wilkinson, R.N., Pouget, C., Gering, M., Russell, A.J., Davies, S.G., Kimelman, D., and Patient, R., Hedgehog and Bmp polarize hematopoietic stem cell emergence in the zebrafish dorsal aorta, 909-916, Copyright (2009) with permission from Elsevier. Full text @ Dev. Cell