ZFIN Image: Kawahara et al., 2011, Fig. S3

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Figure Caption

Fig. S3

Dystrophin morphant by injection of morpholino and the effects of candidate chemicals in recovering the phenotypes of the morphants. The dystrophin morphant has a similar phenotype to the sapje fish, which shows reduced birefringence and expression of dystrophin. (A, C, E, and F) WT. (B, D, G, and H) Dystrophin morphant. (A and B) Normal light image. (C and D) Birefringence image. (E and G) Immunostaining with anti-dystrophin antibody. (F and H) Immunostaining with anti-laminin antibody. (I) Percentage of dead affected and normal fish in morphants with treatment of each of the seven chemicals. In untreated dystrophin morphants, 30% are affected fish. For each chemical treatment, the percentage of affected fish is reduced compared with those of untreated morphants. Blue bar, normal. Red bar, affected fish. Yellow bar, dead fish (*P < 0.01, **P < 0.05; n = 3).

Acknowledgments

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