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Fig. 1 Spatial domains of otic and epibranchial markers at 12 hpf. Dorsal views showing expression of pax8 (A), pax2a (B), fgf24 (C) and sox3 (D) in wild-type embryos at 12 hpf. Otic domains (white dashed lines) and epibranchial domains (black arrows) are indicated. Unlike the other genes, fgf24 expression is limited to the otic domain.
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Reprinted from Developmental Biology, 351(1), Padanad, M.S., and Riley, B.B., Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24, 90-98, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.