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Fig. S2 Inhibition of the Vegf pathway does not affect pancreas development. (A-F) Tg(flk1:GFP) embryos were treated with the Vegf pathway inhibitor SU5416 (5 µM) starting from 6 hpf and examined at 24 hpf under a fluorescence microscope and by in situ hybridization for insulin and pdx1 expression. Although vascular development was disrupted (A,B), insulin (C,D) and pdx1 (E,F) expression patterns appeared unaffected, confirming the specificity of the effect of dorsomorphin on zebrafish pancreas formation.
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