ZFIN Image: North et al., 2010, Fig. 7

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Figure Caption

Fig. 7 Survival after APAP exposure is affected by wnt and PGE2 modulation. (A) Effect of wnt modulation on adult liver morphology and survival after APAP. Wild-type zebrafish were exposed to APAP and 6-bromoindirubin-32-oxime (BIO) (0.5 μM) and/or NAC (10 μM), either concomitantly or with 18-h delay; BIO prevented liver hemorrhage and improved survival, particularly after delayed treatment. (B) wt adult zebrafish were exposed to 10 mM APAP and indomethacin (10 μM), NAC (10 μM), and BIO (0.5 μM). BIO improved survival if given immediately, either alone or with NAC. If given with 18-h delay (del), the combination of BIO and NAC acted synergistically. Indomethacin in combination with APAP was detrimental to survival, which was improved more substantially by BIO than by NAC.

Acknowledgments

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