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Fig. 5
PGE2 acts synergistically with NAC to improve APAP toxicity. (A) Zebrafish embryos were treated with APAP at 48 hpf and with dmPGE2 and/or NAC, either concomitantly or with 12-h delay (del). Combined NAC and PGE2 treatment improved liver morphology, assessed by in situ hybridization for lfabp at 96 hpf, even after delayed exposure. (B) Embryo survival is dependent on treatment parameter and is improved by NAC and PGE2 exposure. (C) Caspase 3/7 activity, as indicator of apoptosis, was measured in a luminometric assay and normalized to controls. *ANOVA, n = 10/ treatment for three replicates, P < 0.001.
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