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Fig. 4 Knockdown of maternal Ship2a affects the expression of FGF-dependent genes in the pre-gastrula embryo. (A,C) mkp3 is expressed dorsally in WT embryos at the oblong stage (3.7 hpf). (B,D) Knockdown of maternal Ship2a results in ventralward expansion of the mkp3 expression domain. (E,F) Expansion of the mkp3 expression domain persists at 50% epiboly (5.3 hpf) in maternal ship2a morphants. (G,H) Expression of erm, a direct target of the FGF signaling pathway, is increased in maternal ship2a morphants. A and B, lateral views with dorsal to the right; C-H, animal pole views with dorsal to the right.