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Fig. S1 Cell death is not responsible for gene expression changes in apc mutant eyes. A,B: TUNEL (terminal deoxynucleotidyl transferase-mediated deoxyuridinetriphosphate nick end-labeling) staining of 48 hours postfertilization (hpf) wild-type (A) and apc mutant (B) eyes. In apc mutant eyes, more cells are undergoing cell death than in wild-type eyes. C,D: In situ hybridization of 48 hpf p53 morpholino injected wild-type and apc mutant embryos with the Wnt/β-catenin pathway target lef1. D: Even in the absence of cell death, apc mutant eyes show an expansion of Wnt/β-catenin target gene expression.
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