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Figure Caption
Fig. S1 Ability of human VANGL1 to rescue the convergent extension defect in tri-MO zebrafish. Panels A-D show lateral views of zebrafish at 2 days post fertilization. In Panel A, an uninjected wild-type fish is shown. In Panel B, a fish injected with tri-MO alone shows a marked shortening of the trunk. In Panel C, 10-25 pg of zebrafish Vangl1 (zVangl1) RNA partially rescued the trunk phenotype induced by co-injection of tri-MO. Co-injection of human VANGL1 (panel D) did rescue the tri-MO induced body length phenotype but at higher doses (50-150 pg).
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Reprinted from Mechanisms of Development, 127(7-8), Reynolds, A., McDearmid, J.R., Lachance, S., Marco, P.D., Merello, E., Capra, V., Gros, P., Drapeau, P., and Kibar, Z., VANGL1 rare variants associated with neural tube defects affect convergent extension in zebrafish, 385-392, Copyright (2010) with permission from Elsevier. Full text @ Mech. Dev.