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Fig. 4

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ZDB-IMAGE-100506-5
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Figures for Nguyen et al., 2010
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Fig. 4 Cardiac differentiation phenotypes of leo1LA1186. Normally, vmhc expression is restricted in the ventricle in wild-type embryos (A), but is expanded into the atrium in leo1LA1186 mutants (B). Expression of amhc, however, is restricted properly to the atrial chamber in both wild-type (C) and leo1LA1186 mutant embryos (D). Notch1b transcripts are detected in the endocardium at the AV boundary of wild-type embryos (E), but are absent in leo1LA1186 mutants (F). Expression of bmp4 (G), versican (I), and wnt2bb (K) are detected in the myocardium of the AV boundary in wild-type embryos. Both bmp4 (H) and versican (J) transcripts are no longer restricted in leo1LA1186 mutants, while wnt2bb is not detected in mutant embryos (L). Dashed lines (in A–D) and arrows (in E, G, I, K) mark the boundary of atrium and ventricle.

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Reprinted from Developmental Biology, 341(1), Nguyen, C.T., Langenbacher, A., Hsieh, M., and Chen, J.N., The Paf1 complex component Leo1 is essential for cardiac and neural crest development in zebrafish, 167-175, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.