ZFIN Image: Hammond et al., 2010, Fig. S6

Image

Figure Caption

Fig. S6 Phenotypes obtained from application of cyclopamine to ptc1^-/-; lep^-/- embryos from time points between 17S and 48 hpf. (A-G) Lateral views of live, 80 hpf ears taken using DIC optics. Corresponding data are shown in Table 3. When cyclopamine was applied from 17S, rescue of the ptc1^-/-; lep^-/- otic phenotype was complete (A). When applied from 48 hpf, the ears remained ptc1^-/-; lep^-/--like (G). From time points in between, the later the cyclopamine was applied, the less complete the rescue (B-F). Anterior to left, dorsal to top. Scale bar: 50 μm. 3 projs, all three canal projections present; ptc1;2, ptc1^-/-; lep^-/-; v proj, only ventral projection present.

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