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Fig. S4 Low doses of cyclopamine can partially rescue the phenotype of the triangular ptc1-/-; lep-/- medial macula to a bow tie shape. (A-D) Merged confocal z-stacks of maculae stained with FITC-phalloidin to reveal the actin-rich stereocilia of the sensory hair cells. Application of 0.5 μM cyclopamine to ptc1-/-; lep-/- embryos rescues the triangular macula phenotype (B) to a bow-tie shape (C) resembling that seen in shh-RNA injected embryos. Lateral views; anterior to left, dorsal to top. Scale bar: 50 μm.
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