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Fig. 7 FGF signaling acts to regulate Xath5 expression through the 3.3 kb enhancer sequence but this effect is not mediated via the 152 bp distal enhancer. Overexpression of XFD mRNA in pG1 X5 3.3 kb transgenic embryos inhibits transgene expression on the injected side (A–B). Ath5 expression is blocked in zebrafish embryos treated with SU5402 vs. DMSO treated embryos (C–D). zc38 transgenic embryos treated with SU5402 express GFP throughout the retina, similar to DMSO treated controls (E–F).
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Reprinted from Developmental Biology, 326(2), Willardsen, M.I., Suli, A., Pan, Y., Marsh-Armstrong, N., Chien, C.B., El-Hodiri, H., Brown, N.L., Moore, K.B., and Vetter, M.L., Temporal regulation of Ath5 gene expression during eye development, 471-481, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.