ZFIN Image: Wilkinson et al., 2009, Fig. 3

Image

Figure Caption

Fig. 3 Bmp Signaling Is Required for Maintenance of runx1 Expression in the Ventral DA but Not for Maintenance of the Arterial Program

(A–H) runx1 expression (arrows) in embryos heat shocked at 22 hpf. runx1 initiated normally, was lost by 24 hpf in GFP⁺ embryos (green letters) compared to GFP^- embryos (black letters), but recovered by 26 hpf. Representative embryos are shown. Embryos containing a few runx1⁺ cells were scored as negative.

(I–P) deltaC expression in the DA (arrows) in embryos heat shocked at 21 hpf was unaffected by inhibition of Bmp signaling.

(Q and R) notch5 expression in the ventral wall of the DA (arrow) in sectioned embryos heat shocked at 21 hpf was normal.

Acknowledgments

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Reprinted from Developmental Cell, 16(6), Wilkinson, R.N., Pouget, C., Gering, M., Russell, A.J., Davies, S.G., Kimelman, D., and Patient, R., Hedgehog and Bmp polarize hematopoietic stem cell emergence in the zebrafish dorsal aorta, 909-916, Copyright (2009) with permission from Elsevier. Full text @ Dev. Cell