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Figure Caption
Fig. S13
NO modifies the effects of wnt signaling on HSC formation.
(A-H) Inducible wnt pathway transgenic embryos were subjected to heatshock at 38°C for 20 mins at 10 somites and then exposed to chemicals (10 μM) until 36 hpf and subjected to runx1/cmyb in situ hybridization.
(A-D) dkk1 induction diminished HSC number, which can be rescued by SNAP.
(E-H) L-NAME inhibited the wnt8-mediated enhancement of HSCs.
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Reprinted from Cell, 137(4), North, T.E., Goessling, W., Peeters, M., Li, P., Ceol, C., Lord, A.M., Weber, G.J., Harris, J., Cutting, C.C., Huang, P., Dzierzak, E., and Zon, L.I., Hematopoietic stem cell development is dependent on blood flow, 736-748, Copyright (2009) with permission from Elsevier. Full text @ Cell