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Fig. S3

ID
ZDB-IMAGE-090320-76
Source
Figures for Jing et al., 2009
Image
Figure Caption

Fig. S3 Genetic interactions between unplugged and wnt11r.
(A) Quantification of motor axon defects at 27 hpf using suboptimal wnt11r TL-MO dose (2 ng). unplugged/+ embryos are indistinguishable from wildtype embryos. The same amount of sub-optimal dose of wnt11r TL-MO injected into wildtype embryos resulted in 13% unplugged-like axonal defects, while injection into unplugged/+ embryos increased the phenotype to 23%. Twenty hemisegments were scored in each embryo; n=hemisegments. Results are compiled from multiple experiments as the average±S.E.M. (t-test, *p<0.01). (B-C) Analysis of prepatterning phenotype using optimal wnt11r TL MO concentrations (3-4 ng) . (B1-B3) Each hemisegment of embryos was scored as normal prepatterning, mild reduction or strong reduction. (C) Quantification data show prepatterning phenotype was increased in unplugged/+ embryos. Results were obtained from three different experiments; n= hemisegments. 3 or 4 hemisegments were scored in each embryo.

Acknowledgments
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