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Figure Caption
Fig. 5 Expression driven by PAX6 HCNE8, human and both zebrafish orthologous sequences. (A–C′) All sequences drive expression to pineal and diencephalon. Left column shows lateral views of 3 days old embryos, right column dorsal views of heads of the same larvae. The signals differ in relative intensity in these structures between human PAX6/pax6a/pax6b. (D) VISTA conservation plot of the alignment of zebrafish pax6a_dr8 and pax6b_dr8 with PAX6_hs8 (baseline) indicating asymmetrical divergence of the zebrafish duplicates. Common peak indicates core HCNE.
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Reprinted from Developmental Biology, 327(2), Navratilova, P., Fredman, D., Hawkins, T.A., Turner, K., Lenhard, B., and Becker, T.S., Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes, 526-540, Copyright (2009) with permission from Elsevier. Full text @ Dev. Biol.