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Fig. 1 The NeuroD fusion protein is functional in vivo. Panels A (wt) and B (transgenic) illustrate embryos from the same clutch treated by heat shock at 15hpf and sacrificed at 25hpf. In the Tg(Hsp70/4:neuroDEGFP) EGFP is expressed throughout the body (cf. arrows in A and B, respectively). Panels C (wt) and D (transgenic) illustrate embryos from the same clutch treated by heat shock and processed for in situ hybridization for islet-1. In the transgenic embryo (D) islet-1 gene expression is induced throughout the body. Scale bars equal 200 μm in A and B.
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Reprinted from Mechanisms of Development, 126(3-4), Ochocinska, M.J., and Hitchcock, P.F., NeuroD regulates proliferation of photoreceptor progenitors in the retina of the zebrafish, 128-141, Copyright (2009) with permission from Elsevier. Full text @ Mech. Dev.