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Fig. 4 In vivo anti-tumor activity.
(A) Compound 13-1-e inhibits proliferation of mouse colon tumor cell line CT26 in vitro. The number of cells treated with 0.3% DMSO serves as the control here. Red fluorescence represents the nuclei revealed by PI staining. (B) Average tumor size of CT26 cells injected in five mice followed by injections of ten doses of DMSO (50 μl) or 13-1-e (dissolved in 50 μl DMSO, 12.5 mg/kg for every two days) are 821 (±345) mm3 (DMSO) and 510 (±107) mm3 (13-1-e). P<0.05.
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