ZFIN Image: Leung et al., 2008, Fig. 4

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Figure Caption

Fig. 4 (A) bmp4 expression was predominantly on the left side of the cardiac cone in comparison to the uniform expression of cmlc2 (inset) which was disrupted in gpr161 knockdown embryos. Graphical summary of control (85.8 ± 3.7%; n = 254), gpr161 knockdown (MO#24, 47.5 ± 5.7%; n = 193) and t-test (p < 0.01) results were from 7 injection experiments. (B) bmp4 expression was predominantly on the left side of the heart tube in comparison to the uniform expression of cmlc2 (inset) was disrupted in gpr161 knockdown embryos. Graphical summary of control (99.5 ± 1.3%; n = 141), gpr161 knockdown (MO#24, 56.9 ± 5.9%; n = 102) and t-test (p < 0.01) results were from 4 injection experiments. Dashed lines were drawn over the cardiac cone and heart tube and the midline of the structures. n was number of total embryos. Error bars were ± SEM. All scale bars were 100 μm.

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Acknowledgments

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Reprinted from Developmental Biology, 323(1), Leung, T., Humbert, J.E., Stauffer, A.M., Giger, K.E., Chen, H., Tsai, H.J., Wang, C., Mirshahi, T., and Robishaw, J.D., The orphan G protein-coupled receptor 161 is required for left-right patterning, 31-40, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.