ZFIN Image: Griffin et al., 2003, Fig. 4

Image

Figure Caption

Fig. 4 Spt and ntl mutant embryos are hypersensitive to FGFR inhibition. (A–C) Embryos from ntl/+ adults. (A) Myosin staining in an untreated ntl mutant embryo. (B) Presumptive ntl mutant embryo treated with 4 μM SU5402; myosin staining is dramatically reduced relative to (A) and (C) ntl +/+ and +/- embryos treated with 4 μM SU5402. (D–F) Embryos obtained from spt/+ adults. (D) Untreated spt mutant embryos have patchy myosin staining in the trunk and segmented staining in the tail. (E) spt mutant embryos treated with 7 μM SU5402 are almost devoid of myosin staining, whereas (F) spt +/+ and +/- embryos treated with 7 μM SU5402 appear similar to untreated wild-type embryos.

Acknowledgments

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Reprinted from Developmental Biology, 264(2), Griffin, K.J. and Kimelman, D., Interplay between FGF, one-eyed pinhead, and T-box transcription factors during zebrafish posterior development, 456-466, Copyright (2003) with permission from Elsevier. Full text @ Dev. Biol.