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Fig. 4 Inhibition of retinal neovascularization by orally active anti-VEGF drugs.
Adult fli-EGFP-Tg zebrafish were exposed to 10 % hypoxia in the absence (A) or presence of sunitinib (B and E) or ZN323881 (C and F) anti-VEGF small molecules for 14 days. Retinal neovascularization was analyzed using whole-mount confocal analysis and quantified as branching points (G), numbers of sprouts (H), intercapillary distances (I), and total vascularization area (J). Yellow arrowheads point to vascular sprouts. Data represents mean determinants of 11–29 randomized samples. *p<0.05. ***p<0.001. Bar = 50 μm.
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