ZFIN Image: Clay et al., 2008, Fig. 7

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Figure Caption

Fig. 7 Increased Cording Seen in the Absence of TNF Signaling Is Not Dependent on the RD1 Virulence Locus or Granuloma Formation

(A) Control (n = 23) and TR1 morphant (n = 9) embryos were infected with 353 ± 10 ΔRD1 bacteria and scored daily for the presence of extracellular bacteria as indicated by cording and plotted as the percentage of embryos with cording. A significantly greater percentage of TR1 morphant embryos display cording versus control embryos at 5 dpi (p < 0.01) and 6 dpi (p < 0.05) as analyzed by Fisher's exact test of a contingency table. (B) and (C) show examples of cording found during infection of TR1 morphant embryos infected with ΔRD1 at 6 dpi. The scale bar represents 25 μm.

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Acknowledgments

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Reprinted from Immunity, 29(2), Clay, H., Volkman, H.E., and Ramakrishnan, L., Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death, 283-294, Copyright (2008) with permission from Elsevier. Full text @ Immunity