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Reprinted from Cell, 134(1), Palamidessi, A., Frittoli, E., Garré, M., Faretta, M., Mione, M., Testa, I., Diaspro, A., Lanzetti, L., Scita, G., and Di Fiore, P.P., Endocytic trafficking of rac is required for the spatial restriction of signaling in cell migration, 135-147, Copyright (2008) with permission from Elsevier. Full text @ Cell