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Fig. 5

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ZDB-IMAGE-080502-11
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Figures for Sanek et al., 2008
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Fig. 5 Zic2a promotes PT formation in cooperation with components of the hedgehog signaling pathway. Embryos of different genetic backgrounds were injected with a conMO (A, C, E) or a zic2aMO (B, D, F) and stained for dlx2a expression by ISH at the prim-5 stage. (A, B) Wild type embryos depleted of Zic2a (B) show a typical reduction of PT relative to control morphants (A). (C) Homozygous syut4 mutant embryos show reduction of PT dlx2a (9/35 embryos, 2 exp.). (D) syut4 mutants depleted of Zic2a exhibit an almost complete loss of dlx2a in the PT (17/74 embryos, 3 exp.). (E) homozygous smob641 embryos show reduced dlx2a expression in the PT (25/83 embryos, 3 exp.). (F) smob641 mutants depleted of Zic2a show complete loss of dlx2a in the PT (60/195 embryos, 4 exp.). Embryos are shown in lateral view, anterior to the left. Arrows point to the PT.

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Reprinted from Developmental Biology, 317(1), Sanek, N.A., and Grinblat, Y., A novel role for zebrafish zic2a during forebrain development, 325-335, Copyright (2008) with permission from Elsevier. Full text @ Dev. Biol.