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Fig. 6 Pituitary defects in Hh pathway mutants. (A, B) Wild-type pituitary expression of (A) lim3 and (B) nk2.2 (arrows). (C, D) smu/smo mutant embryos lack a discernible adenohypophysis and often develop an ectopic lens (arrowhead in D). lim3 (C) and nk2.2 (D) expression is absent in the region. (E, F) yot/gli2-DR mutants have severely reduced or absent lim3 expression and no placodal nk2.2 expression (arrow). (G, H) igu mutants also have reduced or absent lim3 expression and no placodal nk2.2 expression (arrows). (I, J) syu/shh mutants have reduced lim3 expression and no placodal nk2.2 expression (arrows). (K, L) con and (M, N) dtr/gli1 mutants both have moderately reduced lim3 expression and reduced nk2.2 expression. Lateral views of ventral head, eyes removed, anterior to the left. Brackets show anterior/posterior extent of the adenohypophysis when visible. di, diencephalon.
Reprinted from Developmental Biology, 254(1), Sbrogna, J.L., Barresi, M.J., and Karlstrom, R.O., Multiple roles for Hedgehog signaling in zebrafish pituitary development, 19-35, Copyright (2003) with permission from Elsevier. Full text @ Dev. Biol.