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Fig. 3 Isthmic organiser defects. Lateral views of wild-type (A,C,E) and OtxH (B,D,F) brains. (A,B) Most of wnt1 expression is lost in OtxH embryos; weak remaining expression is often observed anterior to the expanded r1. (C-F) fgf8 expression is expanded in the dorsal mes/met territory of OtxH embryos (arrows) at the 5-(D) and 20-somite stages (F). Arrows indicate the isthmic expression, expanded in the morphants.
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