ZFIN Image: Wang et al., 2006, Fig. 2

Image

Figure Caption

Fig. 2 In situ hybridization analysis of Brachyury (T) in early headfold stage Dvl1^-/-; Dvl2^-/- and Lp/Lp mutant embryos. (A) T, a known downstream target gene of the canonical Wnt pathway, was expressed in the notochord, node and primitive streak in control embryos (Dvl1^-/-; Dvl2^+/-). (B) In Dvl1^-/-; Dvl2^-/- mutants, T expression in the node and primitive streak was maintained, suggesting normal activity of the Wnt pathway. However, T expression in the notochord was abnormally widened. T-positive cells were also observed outside of the notochord (arrows), consistent with a disruption of cell movement towards the central midline. Compared with wild-type littermates (C), T expression was also widened in the notochord of Lp/Lp embryos (D). T-positive cells were also observed outside of the notochord (D, arrows).

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Development