ZFIN Image: Lee et al., 2006, Fig. 3

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Figure Caption

Fig. 3 Effects of PTK 787 and FK506 on hemoglobinized blood levels and circulation. Embryos treated with PTK 787 and FK506 as described in Figure 2 were stained with o-dianisidine for circulating hemoglobinized red blood cells (Iuchi and Yamamoto, [1983]) in the yolk sac and heart (30). a: Control embryos at 48 hpf. b: PTK787 treatment for 4 hr had no effect on oxygenated blood levels and circulation. Twelve-hour (c) and 24-hr (d) treatment with PTK 787 resulted in decreased blood in yolk-sac and heart, especially in embryos treated for 24 hr (d). FK506 did not affect oxygenated blood levels or circulation after 4-hr, 12-hr, or 24-hr exposure (panels e, f, g, respectively).

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